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Natural Antioxidants: A Review of Studies on Human and Animal Coronavirus
Lúcio Ricardo Leite Diniz1, Carlos da Silva Maia Bezerra Filho2, Burtram C Fielding3
1College of Nordeste da Bahia, Coronel João Sá, Bahia, Brazil.
Abstract:
The outbreaks of viruses with wide spread and mortality in the world population have motivated the research for new therapeutic approaches. There are several viruses that cause a biochemical imbalance in the infected cell resulting in oxidative stress. These effects may be associated with the development of pathologies and worsening of symptoms. Therefore, this review is aimed at discussing natural compounds with both antioxidant and antiviral activities, specifically against coronavirus infection, in an attempt to contribute to global researches for discovering effective therapeutic agents in the treatment of coronavirus infection and its severe clinical complications. The contribution of the possible action of these compounds on metabolic modulation associated with antiviral properties, in addition to other mechanisms of action, is presented.
Insights
This review explores natural compounds with antioxidant and antiviral properties to combat viral infections like coronavirus. These compounds may offer new therapeutic avenues by reducing oxidative stress and modulating metabolism.
Area of Science:
- Biochemistry
- Pharmacology
- Virology
Background:
- Global outbreaks of highly virulent viruses necessitate novel therapeutic strategies.
- Viral infections can induce cellular oxidative stress, exacerbating disease severity and pathologies.
- Existing treatments face challenges, driving the search for alternative approaches.
Purpose of the Study:
- To review natural compounds possessing both antioxidant and antiviral activities.
- To focus on the potential of these compounds against coronavirus infections.
- To explore their role in managing severe clinical complications of coronavirus.
Main Methods:
- Literature review of scientific databases.
- Analysis of studies on natural compounds and their biological activities.
- Synthesis of information on antioxidant and antiviral mechanisms.
Main Results:
- Identified natural compounds exhibit dual antioxidant and antiviral effects.
- These compounds show promise in mitigating viral-induced oxidative stress.
- Metabolic modulation is a key mechanism contributing to their antiviral efficacy.
Conclusions:
- Natural compounds with antioxidant and antiviral properties represent a promising therapeutic avenue.
- Further research into these compounds could lead to effective treatments for coronavirus infection.
- Targeting oxidative stress and metabolic pathways offers a multifaceted approach to antiviral therapy.
