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Updated: Dec 10, 2025
09:02
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
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Do hepatic artery infusion pumps cause recurrent pleural effusions?
Emily Ann Harris1, Rafael Garza Castillon1, Priya Bhakta1
1Amita Saint Joseph Hospital, 2900 N Lakeshore Drive, Chicago, IL, USA.
Journal of Surgical Case Reports
|August 29, 2020
Summary
Hepatic artery infusion pump chemotherapy (HAIPC) can cause recurrent pleural effusions in colorectal liver metastasis patients. This side effect may stem from perihepatic inflammation and warrants further investigation.
Area of Science:
- Oncology
- Gastroenterology
- Pulmonology
Background:
- Colorectal liver metastasis (CRLM) treatment often involves chemotherapy.
- Hepatic artery infusion pump chemotherapy (HAIPC) is an emerging technique for CRLM.
- The side effect profile of HAIPC, particularly concerning pleural effusions, is not well-documented.
Observation:
- A case report details a 48-year-old male with CRLM undergoing HAIPC.
- The patient developed recurrent, benign/transudative pleural effusions.
- These effusions were diagnosed after right-side video-assisted thoracoscopic surgery.
Findings:
- HAIPC is suggested to induce recurrent sympathetic pleural effusions.
- This effusion is likely a side effect of perihepatic inflammation from localized chemotherapy.
- The study raises questions about whether these effusions precede hepatic toxicity.
Implications:
- This finding aids in the differential diagnosis of pleural effusions in cancer patients receiving HAIPC.
- It highlights a potential adverse event associated with HAIPC therapy.
- Further research is needed to confirm the link between HAIPC, pleural effusions, and hepatic toxicity.
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