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MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy

Mostafa Abdelsalam1, A M Wahab1, Maysaa El Sayed Zaki2

  • 1Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

International Journal of Nephrology
|August 29, 2020
PubMed
Abstract

Insights

MicroRNA-451 shows potential as an early diagnostic marker for diabetic nephropathy, offering higher sensitivity and specificity than traditional markers for chronic kidney disease. This microRNA can aid in early detection and management of kidney complications in diabetes patients.

Area of Science:

  • Biochemistry
  • Genetics
  • Nephrology

Background:

  • Diabetes mellitus is a primary cause of end-stage renal disease globally.
  • Microalbuminuria is a key diagnostic marker for diabetic nephropathy but lacks early diagnostic sensitivity.
  • MicroRNAs are emerging as potential early diagnostic markers and therapeutic targets for diabetic nephropathy progression.

Purpose of the Study:

  • To evaluate microRNA-451 as an early diagnostic biomarker for diabetic nephropathy.
  • To compare microRNA-451 expression levels with traditional markers of kidney function in type 2 diabetes patients.

Main Methods:

  • Ninety patients with type 2 diabetes and 30 controls were included.
  • Real-time PCR was used to measure microRNA-451 expression in blood and plasma.
  • Serum creatinine, urinary albumin, and estimated glomerular filtration rate (eGFR) were assessed as standard markers.

Main Results:

  • Significant differences in serum creatinine, eGFR, and microRNA-451 levels were observed between diabetic patients and controls (p=0.0001).
  • Lower eGFR (<60 ml/min/1.73 m²) correlated with higher plasma microRNA-451 and lower urinary microRNA-451 (p=0.0001).
  • Plasma and urinary microRNA-451 demonstrated high sensitivity and specificity for detecting chronic kidney disease in diabetic nephropathy.

Conclusions:

  • MicroRNA-451 is a promising early biomarker for chronic kidney disease in diabetic nephropathy.
  • Its high sensitivity and specificity suggest a valuable role in early diagnosis and disease monitoring.
  • MicroRNA-451 may contribute to better management strategies for diabetic kidney disease.

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