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Related Experiment Video

Updated: Dec 10, 2025

Novel Process for 3D Printing Decellularized Matrices
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3D Printing metamaterials towards tissue engineering.

Elvan Dogan1, Anant Bhusal1, Berivan Cecen2

  • 1Biofabrication Lab, Department of Mechanical Engineering, Rowan University, Glassboro, NJ 08028, United States.

Applied Materials Today
|August 29, 2020
PubMed
Summary

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This review explores advanced 3D printing for creating mechanical metamaterials with unique properties. It guides selecting fabrication parameters for meta-biomaterials in tissue engineering.

Area of Science:

  • Materials Science
  • Biotechnology
  • Engineering

Background:

  • Three-dimensional (3D) printing technology is rapidly advancing, necessitating research into its fundamental fabrication concepts and capabilities.
  • A growing trend involves using 3D printing to create mechanical metamaterials, where properties arise from structural organization rather than material composition.
  • These metamaterials exhibit unique mechanical behaviors like ultra-lightweight, super-elasticity, and auxetic properties, despite using identical material compositions.

Purpose of the Study:

  • To review current advancements in the design and fabrication of multi-scale advanced structures with novel properties.
  • To classify and compare different fabrication methods for creating these advanced materials.
  • To provide guidelines for selecting fabrication parameters for constructing meta-biomaterials specifically for tissue engineering applications.
Keywords:
Additive manufacturingBioprintingMetamaterialsMultiscaleTissue engineering

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Main Methods:

  • Literature review of current advancements in the design and fabrication of multi-scale advanced structures.
  • Classification of fabrication methods into conventional methods, additive manufacturing techniques, and 4D printing.
  • Comprehensive comparison of the identified fabrication methods.

Main Results:

  • Identification and review of multi-scale advanced structures with unprecedented properties.
  • Classification and comparative analysis of fabrication techniques including conventional, additive manufacturing, and 4D printing.
  • Development of guidelines for selecting fabrication parameters for meta-biomaterials.

Conclusions:

  • Advanced 3D printing enables the creation of materials with emergent properties through structural design.
  • Additive manufacturing and 4D printing offer promising avenues for fabricating complex meta-biomaterials.
  • Key parameters such as multi-material capacity, resolution, speed, and biocompatibility are crucial for successful meta-biomaterial fabrication in tissue engineering.