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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Burn Injuries01:22

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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Related Experiment Video

Updated: Dec 10, 2025

A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

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Systemic factors that shape cutaneous pathological scarring.

Chenyu Huang1, Rei Ogawa2

  • 1Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|August 29, 2020
PubMed
Summary
This summary is machine-generated.

Systemic factors like cytokines and hormones influence pathological scars, such as keloids. New research exploring keloid-tumor similarities and stem cells may lead to better diagnostics and treatments.

Keywords:
diet preferencekeloidslifestyle profilemolecular circulating changes

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Area of Science:

  • Dermatology
  • Pathology
  • Molecular Biology

Background:

  • Cutaneous pathological scars, particularly keloids, are characterized by continuous growth, inflammation, and pain.
  • The exact causes of pathological scarring are unknown but involve genetic, mechanical, and systemic factors.
  • Existing research often focuses on fibrosis, neglecting other scar characteristics influenced by systemic factors.

Purpose of the Study:

  • To review systemic factors contributing to pathological scarring, especially keloid formation and worsening.
  • To explore novel research directions, including keloid-tumor similarities and stem cell populations.
  • To identify potential diagnostic biomarkers and therapeutic strategies for pathological scars.

Main Methods:

  • Literature review and synthesis of current research on systemic factors in scar formation.
  • Analysis of circulating factors (cytokines, hormones, etc.) and their impact on scar hallmarks (angiogenesis, inflammation, fibrosis).
  • Exploration of emerging research areas in keloid pathology.

Main Results:

  • Systemic factors such as circulating cytokines, hormones, and vitamin D directly influence scar angiogenesis, inflammation, fibrosis, and remodeling.
  • Environmental factors like diet, smoking, stress, and exercise indirectly affect scar progression.
  • Similarities between keloids and tumors, and distinct stem cell populations in keloids are identified as key research areas.

Conclusions:

  • Systemic factors play a crucial role in shaping various characteristics of pathological scars.
  • Further research into keloid-tumor similarities and stem cells holds promise for advancing scar understanding.
  • This research may facilitate the development of diagnostic tools and novel treatments for pathological scarring.