Photoinduced iodine-mediated tandem dehydrogenative Povarov cyclisation/C-H oxygenation reactions
Eva Schendera1, Alexander Villinger, Malte Brasholz
1University of Rostock, Institute of Chemistry, Albert-Einstein-Str. 3A, 18055 Rostock, Germany. malte.brasholz@uni-rostock.de.
Abstract:
We report metal-free, photoinduced aerobic tandem dehydrogenative Povarov cyclisation/Csp-H oxygenation reactions between N-aryl glycine esters and α-substituted styrenes, which efficiently lead to 4,4-disubstituted dihydroquinoline-3-ones under mild conditions. The reactions are mediated by iodine along with visible light irradiation, which allows for the in situ generation of the essential Brønsted acid HI, to catalyse the key imine [4+2]-cycloaddition.
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