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In vitro tests for immediate hypersensitivity.

A I Terr1

  • 1Department of Medicine, Stanford University Medical Center, California 94305.

Annual Review of Medicine
|January 1, 1988
PubMed
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In vitro tests for IgE antibodies aid in diagnosing allergic diseases, especially in workplace settings or when skin tests are risky. However, clinicians must understand their limitations compared to skin testing.

Area of Science:

  • Immunology
  • Allergology

Background:

  • In vitro measurement of IgE antibodies is crucial for studying allergic disease.
  • The role of these tests in routine diagnosis remains under-established.

Purpose of the Study:

  • To evaluate the utility and limitations of in vitro IgE antibody testing in allergy diagnosis.
  • To highlight specific applications where in vitro tests are advantageous.

Main Methods:

  • The radioallergosorbent test (RAST) is the fundamental in vitro procedure.
  • Various modifications of RAST exist, each with unique pros and cons.

Main Results:

  • In vitro tests are valuable for identifying workplace allergens.
  • They are useful when skin testing is hazardous or impractical.

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Conclusions:

  • Clinicians must be aware of technical challenges and sensitivity limitations of in vitro tests.
  • In vitro tests detect IgE antibodies but do not directly confirm their role in causing allergic reactions.