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Published on: June 13, 2012
Three novel pterosin dimers form Pteris obtusiloba
Caiying Peng1, Jian Lu1, Jianqun Liu1
1Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004 Nanchang, People's Republic of China.
Abstract:
Three novel pterosin dimmers, named as obtupterosin A (1), B (2) and C (3), together with eight known pterosins (4-11) were isolated from Pteris obtusiloba. Their structures were elucidated on the basis of ESI-MS, 1D and 2D NMR spectral data, CD, X-ray and literature comparisons. Compounds 1 and 2 were a pair of isomers. Compounds 1 and 3 were the novel type of pterosin dimer. The new compounds (1-3) were assessed for their cytotoxic activities and their α-glucosidase inhibition activity. Compounds 1-3 exhibited cytotoxic activity against HCT-116 cells with IC50 value of 27.5 μM, 30.6 μM and 12.8 μM, respectively. However, all were found to be inactive at 200 μM for α-glucosidase inhibition.
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