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Updated: Dec 10, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
SARS-CoV-2 another kind of liver aggressor, how does it do that?
Sonia A Lozano-Sepulveda1, Kame Galan-Huerta1, Natalia Martínez-Acuña1
1Department of Biochemistry and Molecular Medicine, School of Medicine and Hospital Universitario "Dr. Jose E. Gonzalez", Autonomous University of Nuevo León, Monterrey, N.L, Mexico.
Abstract:
Clinical manifestations of SARS-CoV-2 infection include more frequently fever and cough, but complications (such as pneumonia, respiratory distress syndrome, and multiorgan failure) can occur in persons with additional comorbidities. Liver dysfunction is one of the most striking affections among patients suggesting that SARS-CoV-2 may represent a new king of liver aggressor. However, the molecular process underlying this phenomenon is still unclear. In this work, we overview the most recent findings between the molecular biology of the virus, pathogenic mechanisms, and its relationship to liver disease observed in patients.
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