A multi-modal virtual reality treadmill intervention for enhancing mobility and cognitive function in people with...

Area of Science:

• Neurology
• Rehabilitation Science
• Human Movement Science

Background:

• Gait and cognitive impairments are prevalent in Multiple Sclerosis (MS), impacting daily function.
• Dual-task interference, the difficulty of performing walking and cognitive tasks simultaneously, is a key challenge for individuals with MS.
• Dual-task training and virtual reality (VR) offer potential avenues for improving functional ambulation and personalized rehabilitation.

Purpose of the Study:

• To evaluate the efficacy of a combined cognitive-motor virtual reality (VR) training program for improving MS symptoms.
• To compare the benefits of VR-enhanced dual-task training against conventional treadmill training in individuals with MS.
• To investigate the impact of targeted dual-task training on functional ambulation and information processing speed in MS.

Main Methods:

• A single-blinded, two-arm randomized controlled trial (RCT) with 144 participants with MS.
• A six-week intervention period involving 18 training sessions.
• Comparison between a treadmill training group and a treadmill training with virtual reality group, with VR group receiving system feedback.

Main Results:

• Primary outcomes include dual-task gait speed and information processing speed.
• Measurements taken pre-training, one week post-training, and three months post-training.
• Anticipated significant improvements in dual-task gait speed and information processing speed for the VR group compared to the control group.

Conclusions:

• The study aims to provide insights into the effectiveness of multi-modal cognitive-motor interventions for reducing dual-task costs in MS.
• This research is powered to determine if targeted dual-task training can enhance MS symptoms and functional ambulation.
• Findings are expected to demonstrate superior outcomes for VR-integrated training in improving gait and cognitive performance in MS patients.