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Obstructive sleep apnea, shift work and cardiometabolic risk
Inês Santos1, Isabel Rocha2, David Gozal3
1Sleep Unit, Cardiovascular Center of University of Lisbon, Lisbon School of Medicine, Lisbon, Portugal.
Sleep Medicine
|August 29, 2020
Summary
Shift work disrupts circadian rhythms, potentially worsening cardiometabolic risk in Obstructive Sleep Apnea (OSA) patients. Autonomic modulation may link these conditions, offering new insights into OSA
Area of Science:
- Cardiology
- Sleep Medicine
- Chronobiology
Background:
- Obstructive Sleep Apnea (OSA) is a common sleep disorder linked to adverse health outcomes and increased cardiometabolic risk.
- Shift work (SW) significantly disrupts circadian rhythms and impacts cardiometabolic health.
- The interaction between the circadian timing system (CTS) and the autonomic nervous system (ANS) is crucial, especially in OSA patients.
Purpose of the Study:
- To investigate whether SW-induced circadian misalignment exacerbates cardiometabolic risk in OSA patients.
- To explore the role of autonomic modulation as a mechanism linking OSA, circadian misalignment, and cardiometabolic risk.
Main Methods:
- This is a review, synthesizing existing literature on OSA, shift work, circadian rhythms, and cardiometabolic health.
- The review focuses on the interplay between the CTS, ANS, and cardiometabolic outcomes in the context of OSA and SW.
Main Results:
- Shift work's disruption of circadian rhythms may potentiate cardiometabolic risk in individuals with OSA.
- Autonomic modulation is proposed as a key downstream pathway connecting OSA and circadian misalignment to cardiometabolic risk.
Conclusions:
- Circadian misalignment due to shift work could represent a significant risk factor for cardiometabolic complications in OSA patients.
- Understanding autonomic modulation offers a novel perspective for managing cardiometabolic risk in this population.
Keywords:
Autonomic nervous systemCardiometabolic riskCircadian misaligmentCircadian rhythmsObstructive sleep apneaShift workMore Related Videos
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