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Radiotherapy of non-tumoral refractory neurological pathologies
J Jacob1, N Reyns2, C-A Valéry3
1Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles-Foix, Department of Radiation Oncology, 47-83, boulevard de l'Hôpital, 75013 Paris, France.
Intracranial stereotactic radiotherapy, or radiosurgery, offers an effective treatment for non-tumoral brain conditions like arteriovenous malformations and trigeminal neuralgia. This precise radiation technique provides an advantageous benefit/risk ratio for patients with disabling neurological symptoms.
Area of Science:
- Neurology
- Radiation Oncology
- Neurosurgery
Background:
- Intracranial radiotherapy has advanced with stereotactic techniques.
- Intracranial stereotactic body radiotherapy is primarily used for tumors but also effective for other neurological conditions.
Purpose of the Study:
- To review the role of intracranial stereotactic body radiotherapy in managing non-tumoral, refractory neurological pathologies.
- To define the place of this advanced radiotherapy in patient management.
Main Methods:
- Literature review of intracranial stereotactic body radiotherapy applications.
- Focus on GammaKnife® and linear accelerator delivery systems.
- Emphasis on high-precision radiotherapy techniques.
Main Results:
- Radiosurgery is effective for brain arteriovenous malformations, offering an improved benefit/risk ratio.
- It is also beneficial for disabling symptoms like trigeminal neuralgia and tremors (essential or Parkinson's-related).
Conclusions:
- Intracranial stereotactic body radiotherapy is a valuable option for specific non-tumoral neurological conditions.
- Multidisciplinary collaboration among Neurosurgery, Neurology, Neuroradiology, Radiation Oncology, and Medical Physics is crucial for successful high-precision procedures.
