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Small airways' function in Obstructive Sleep Apnea-Hypopnea Syndrome.

K Giannadaki1, S Schiza1, G Vavougios2

  • 1Department of Thoracic Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece; Sleep Disorders Center, Medical School, University of Crete, Heraklion, Crete, Greece.

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|August 30, 2020
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Summary
This summary is machine-generated.

Small airway function is impaired in patients diagnosed with Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). This dysfunction may influence the condition's progression and suggests potential new treatments targeting small airways.

Keywords:
HelioxIsoflowLung mechanicsPhysiologySleep disorders

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Area of Science:

  • Pulmonary Medicine
  • Sleep Medicine
  • Respiratory Physiology

Background:

  • Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) research typically focuses on upper airway issues.
  • The role of small airways in OSAHS pathophysiology requires further investigation.

Purpose of the Study:

  • To investigate small airway function in patients diagnosed with OSAHS.
  • To determine if OSAHS affects small airway mechanics.

Main Methods:

  • 23 patients with OSAHS and 8 healthy controls underwent polysomnography and spirometry.
  • Breathing air and an 80%He-20%O2 mixture assessed small airway function using VisoV⋅ and ΔV˙max50%.

Main Results:

  • VisoV⋅ was significantly elevated in OSAHS patients versus controls (p=0.004).
  • No significant differences were observed in ΔV˙max50% (p=0.551), MEF25-75% (p=0.067), or MEF50% (p=0.174).

Conclusions:

  • Small airway function is demonstrably affected at the time of OSAHS diagnosis.
  • Impaired small airway function may result from low lung volumes and cyclic airway events.
  • Findings suggest potential for novel therapeutic strategies targeting small airways in OSAHS management.