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Small airways' function in Obstructive Sleep Apnea-Hypopnea Syndrome.
K Giannadaki1, S Schiza1, G Vavougios2
1Department of Thoracic Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece; Sleep Disorders Center, Medical School, University of Crete, Heraklion, Crete, Greece.
Pulmonology
|August 30, 2020
Summary
Small airway function is impaired in patients diagnosed with Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). This dysfunction may influence the condition's progression and suggests potential new treatments targeting small airways.
Area of Science:
- Pulmonary Medicine
- Sleep Medicine
- Respiratory Physiology
Background:
- Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) research typically focuses on upper airway issues.
- The role of small airways in OSAHS pathophysiology requires further investigation.
Purpose of the Study:
- To investigate small airway function in patients diagnosed with OSAHS.
- To determine if OSAHS affects small airway mechanics.
Main Methods:
- 23 patients with OSAHS and 8 healthy controls underwent polysomnography and spirometry.
- Breathing air and an 80%He-20%O2 mixture assessed small airway function using VisoV⋅ and ΔV˙max50%.
Main Results:
- VisoV⋅ was significantly elevated in OSAHS patients versus controls (p=0.004).
- No significant differences were observed in ΔV˙max50% (p=0.551), MEF25-75% (p=0.067), or MEF50% (p=0.174).
Conclusions:
- Small airway function is demonstrably affected at the time of OSAHS diagnosis.
- Impaired small airway function may result from low lung volumes and cyclic airway events.
- Findings suggest potential for novel therapeutic strategies targeting small airways in OSAHS management.
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