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12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
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Current evidence on screening for renal cancer
Juliet Usher-Smith1, Rebecca K Simmons2, Sabrina H Rossi3
1The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Nature Reviews. Urology
|August 30, 2020
Summary
Screening for renal cell carcinoma (RCC) may be cost-effective, especially for high-risk individuals. Further research is needed to determine optimal screening methods, target populations, and potential harms before widespread implementation.
Area of Science:
- Urology
- Oncology
- Public Health
Background:
- Global incidence of renal cell carcinoma (RCC) is rising.
- Many patients are asymptomatic at diagnosis, despite RCC's high mortality rate.
- These factors suggest RCC may be a candidate for screening.
Purpose of the Study:
- To analyze the potential cost-effectiveness of RCC screening.
- To identify optimal strategies for targeted screening of high-risk populations.
- To address uncertainties regarding screening benefits, modalities, and implementation.
Main Methods:
- Analysis of potential cost-effectiveness of RCC screening.
- Review of factors influencing screening benefits and harms.
- Identification of areas requiring further research before a full trial.
Main Results:
- RCC screening shows potential for cost-effectiveness, particularly when targeted.
- Significant uncertainties remain regarding treatment benefits, optimal screening methods, and target populations.
- Further research is essential to address these uncertainties.
Conclusions:
- Targeted screening for renal cell carcinoma (RCC) may be cost-effective.
- Further research is required to optimize screening programs, including risk prediction, non-invasive detection methods, feasibility, and potential harms.
- Addressing these uncertainties is crucial before implementing large-scale screening initiatives.
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