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Quercetin attenuates cisplatin-induced fat loss
Yi-Chin Lin1, Li-Wen Chen1, Yun-Chu Chen1
1Department of Nutritional Science, Chung Shan Medical University, No. 110 Sec 1 Jianguo N. Rd, Taichung, Taiwan, ROC.
European Journal of Nutrition
|August 30, 2020
Summary
Quercetin, a flavonoid, can help reduce chemotherapy-induced fat loss by regulating fat metabolism genes. This study investigated quercetin
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Cisplatin (CDDP) chemotherapy can cause significant unintended fat loss.
- Flavonoids, like quercetin, are plant compounds with potential therapeutic benefits.
Purpose of the Study:
- To investigate the effects of quercetin on mitigating cisplatin (CDDP)-induced cachexia (fat loss).
- To elucidate the underlying mechanisms of quercetin's action on fat metabolism during CDDP treatment.
Main Methods:
- Administered CDDP with varying doses and methods of quercetin (dietary or intraperitoneal) to tumor-bearing and tumor-free mice.
- Utilized 3T3-L1 cells to assess quercetin's impact on CDDP-induced fat accumulation.
- Analyzed gene expression related to fat metabolism in response to treatments.
Main Results:
- Quercetin enhanced CDDP's anticancer effects by modulating p53 and p21 pathways.
- Quercetin attenuated CDDP-induced fat loss in mice and suppressed fat accumulation in 3T3-L1 cells.
- Quercetin normalized fat metabolism-associated gene expression in epididymal fat tissue despite unchanged food intake.
Conclusions:
- Quercetin demonstrates potential in suppressing cisplatin-induced fat loss.
- Regulation of fat metabolism-associated gene expression is a likely mechanism for quercetin's protective effect.
