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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Updated: Dec 10, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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A 3D Organotypic Melanoma Spheroid Skin Model

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Morphological evolution in melanoma in situ using revised pattern analysis.

Rajan Ramji1, Amanda Oakley1, Marius Rademaker1

  • 1Waikato Clinical Campus, University of Auckland, Hamilton, New Zealand.

Pigment Cell & Melanoma Research
|August 30, 2020
PubMed
Summary
This summary is machine-generated.

Sequential digital dermoscopic imaging reveals melanoma in situ (MIS) features evolve over time. Lesions increase in complexity, indicating potential for malignancy development with longer follow-up.

Keywords:
dermoscopyearly detectionmelanoma in siturevised pattern analysissequential digital dermoscopic imaging

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Area of Science:

  • Dermatology
  • Oncology
  • Medical Imaging

Background:

  • Melanoma in situ (MIS) requires accurate monitoring for malignant transformation.
  • Sequential digital dermoscopic imaging (SDDI) allows serial assessment of skin lesions.
  • Understanding dermoscopic changes in MIS is crucial for early detection.

Purpose of the Study:

  • To investigate the evolution of dermoscopic features associated with malignancy in melanoma in situ using retrospective SDDI data.
  • To correlate changes in dermoscopic features over time with potential for histopathological progression.

Main Methods:

  • Retrospective analysis of 124 in situ melanomas from 110 Caucasian patients (≥18 years).
  • Utilized serial dermoscopic images (≥2 per lesion) obtained between 1999-2017, with a mean follow-up of 41 months.
  • Included 58 invasive melanomas as a positive control group.

Main Results:

  • Melanoma in situ size and color count significantly correlated with time (p < .001).
  • Odds of MIS displaying ≥3 malignancy clues increased with time (OR 5.6-52.1, p < .05).
  • Most lesions (75%) matched a dermoscopic subtype on final imaging, with predominant increase in morphological complexity over time.

Conclusions:

  • Melanoma in situ lesions demonstrate evolving dermoscopic features over time.
  • Longer follow-up periods are essential for observing the development of malignancy-associated dermoscopic features and histopathological progression.
  • SDDI is valuable for monitoring subtle changes indicative of melanoma progression.