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06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
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IgA vasculitis during secukinumab therapy.
Dijana Perkovic1, Petra Simac1, Josip Katic2
1Clinic for Internal Medicine, University Hospital Split, Spinciceva 1, 21 000, Split, Croatia.
Clinical Rheumatology
|August 30, 2020
Summary
Secukinumab effectively treats psoriatic arthritis but can rarely trigger Henoch-Schönlein purpura vasculitis. Early diagnosis of this rare adverse event is crucial for patient recovery and quality of life.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Psoriatic arthritis is a chronic inflammatory condition linked to psoriasis.
- Treatment for psoriatic arthritis includes non-pharmacologic methods, NSAIDs, DMARDs, and biologics.
- Secukinumab, an interleukin-17 (IL-17) inhibitor, is approved for psoriatic arthritis treatment.
Observation:
- Clinicians must be aware of rare adverse events associated with IL-17 inhibitors.
- A 39-year-old patient developed Henoch-Schönlein purpura vasculitis.
- This vasculitis was induced by secukinumab treatment.
Findings:
- Secukinumab, an anti-IL-17 biologic, can induce cutaneous vasculitis.
- Henoch-Schönlein purpura vasculitis is a rare but serious adverse event.
- The case highlights a previously unobserved side effect in clinical trials.
Implications:
- Awareness of potential cutaneous vasculitis triggered by anti-IL-17 therapy is essential.
- Early diagnosis of vasculitis improves patient outcomes and reduces morbidity.
- Prompt recognition and management can mitigate the impact on quality of life.
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