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Related Concept Videos

Atherosclerosis I: Introduction01:30

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Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
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Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

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Extracellular vesicle signalling in atherosclerosis.

E Charla1, J Mercer1, P Maffia2

  • 1Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UK.

Cellular Signalling
|August 30, 2020
PubMed
Summary

Extracellular vesicles (EVs) play a key role in atherosclerosis progression by mediating cell signalling. EV signatures show promise as potential biomarkers for this cardiovascular disease.

Keywords:
AtherosclerosisCoronary artery disease (CAD)Extracellular vesicles (EVs)microRNA (miRNA)

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Area of Science:

  • Cardiovascular Science
  • Cell Biology
  • Biochemistry

Background:

  • Atherosclerosis is a leading cause of global mortality, driven by arterial wall inflammation and lipid deposition.
  • Plaque rupture in atherosclerosis can lead to myocardial infarction and stroke.
  • Extracellular vesicles (EVs) are crucial for intercellular communication, transporting various biomolecules.

Purpose of the Study:

  • To review current knowledge on extracellular vesicle (EV) signalling in atherosclerosis.
  • To explore the potential of EV signatures as biomarkers for atherosclerosis.

Main Methods:

  • Literature review of studies on EVs and atherosclerosis.
  • Analysis of EV involvement in cellular processes during disease progression.

Main Results:

  • EVs are present in atherosclerotic plaques and influence key processes like inflammation, immune response, and vascular remodeling.
  • EVs mediate cell-cell communication, contributing to atherosclerosis development and progression.

Conclusions:

  • EV signalling is integral to atherosclerosis pathogenesis.
  • EV signatures represent a promising avenue for developing novel diagnostic biomarkers for atherosclerosis.