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CHI3L1 in the pathophysiology and diagnosis of liver diseases
Shuwei Wang1, Mengyuan Hu2, Yunsong Qian1
1Department of Hepatology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China; Medical School of Ningbo University, Ningbo 315211, China.
Abstract:
Chitinase 3-like protein 1(CHI3L1) participates in physiological and pathophysiological process, such as cell survival, cell proliferation, tissue remodeling, angiogenesis, etc. Some studies demonstrated that CHI3L1 is liver-enriched and has better application value in staging liver fibrosis than platelet ratio index(APRI) and fibrosis-4 index(FIB-4) and that CHI3L1 can be used in monitoring the prognosis of hepatocellular carcinoma (HCC). In this review, we summarized the pathophysiological role and the diagnostic value of CHI3L1 in liver fibrosis in different background and HCC.
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