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Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study
José L Hernández1, Cristina Baldeón2, Ana E López-Sundh3
1Division of Internal Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
Insights
The atherogenic index of plasma (AIP) is significantly linked to hidradenitis suppurativa (HS) severity. Higher AIP levels correlate with more severe HS, independent of other risk factors.
Area of Science:
- Cardiology
- Dermatology
- Biochemistry
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- HS is linked to comorbidities and vascular risks like dyslipidemia.
- The relationship between lipid profiles and HS severity requires further investigation.
Purpose of the Study:
- To investigate associations between lipid profiles, atherogenic indexes, and HS severity.
- To determine if specific lipid parameters predict HS progression.
Main Methods:
- A case-control study involving 78 HS patients and 62 healthy controls.
- Evaluation of classic lipid profiles, lipoprotein ratios, and the atherogenic index of plasma (AIP).
- HS severity assessed using the HS Physician Global Assessment (PGA).
Main Results:
- HS patients exhibited lower total cholesterol and HDL-C, and higher AIP compared to controls.
- AIP positively correlated with BMI, blood pressure, LDL-C, triglycerides, and inflammatory markers.
- AIP was independently associated with increased HS severity (PGA ≥ 3) after adjusting for confounders.
Conclusions:
- The atherogenic index of plasma (AIP) is significantly and independently associated with HS severity.
- AIP may serve as a potential biomarker for assessing HS progression and associated vascular risks.
Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with several comorbidities and vascular risk factors, such as dyslipidemia. The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS.
Methods:
This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA).
Results:
HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, non-HDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA ≥ 3) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (r = 0.268; p = 0.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP ≥ 0.11 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09-17.50; p = 0.037).
Conclusions:
In conclusion, these results showed that AIP is significantly and independently associated with HS severity.
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