Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

767
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
767

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Center Randomized Trial Evaluating the Safety and Effectiveness of the Instylla Hydrogel Embolic System (HES) for Vascular Occlusion of Hypervascular Tumors.

Journal of vascular and interventional radiology : JVIR·2026
Same author

Reply to: Methodologic Considerations for Subsequent Colorectal Cancer in Survivors of Childhood Cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

A Prospective Validation of the Decipher Genomic Classifier in Men With Early Localized Prostate Cancer: The VANDAAM Study.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

Dose-Volume Histogram Compendium of Dose Constraints for Treatment Planning: An ASTRO Consensus Paper.

Practical radiation oncology·2026
Same author

Breast cancer recurrence and mortality among survivors of childhood cancer.

Journal of the National Cancer Institute·2026
Same author

International Guideline Harmonization Group Recommendations for Breast Cancer Surveillance in Childhood, Adolescent, and Young Adult Cancer Survivors After Anthracyclines.

JCO oncology practice·2026

Related Experiment Video

Updated: Dec 10, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.4K

Temporary Organ Displacement to Escalate Radiation Dose to Retroperitoneal Tumors and Decrease Toxicity to Organs at

Majid Maybody1, Mohamed M Soliman1, Yoshiya Yamada2

  • 1Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Journal of Vascular and Interventional Radiology : JVIR
|August 31, 2020
PubMed
Summary

Temporary organ displacement (TOD) using drainage catheters and hydrodissection is a feasible and safe technique. This method effectively displaces organs at risk (OAR) from the gross tumor volume (GTV), enabling successful radiation treatment.

More Related Videos

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.7K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.3K

Related Experiment Videos

Last Updated: Dec 10, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.4K
Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

14.7K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.3K

Area of Science:

  • Radiation Oncology
  • Medical Imaging
  • Surgical Techniques

Background:

  • Accurate radiation delivery requires precise targeting of the gross tumor volume (GTV) while sparing organs at risk (OAR).
  • Minimizing overlap between GTV and OAR is crucial for reducing treatment toxicity and improving efficacy.
  • Temporary organ displacement (TOD) offers a potential strategy to create space between the GTV and OAR.

Purpose of the Study:

  • To evaluate the feasibility and reproducibility of temporary organ displacement (TOD) using drainage catheter placement and hydrodissection.
  • To assess the effectiveness of TOD for both simulation (SIM) and stereotactic body radiation treatment (SBRT).
  • To determine if TOD can create and maintain a sufficient separation between the GTV and OAR.

Main Methods:

  • A prospective study involving 31 patients undergoing SIM and SBRT with TOD between 2010 and 2018.
  • TOD was achieved using hydrodissection and drainage catheter placement to displace the OAR from the GTV.
  • Displacement was measured on computed tomography (CT) images during TOD, SIM, and SBRT, with a minimum 10 mm separation required.

Main Results:

  • TOD significantly increased OAR-GTV separation (median 20 mm vs. 4.1 mm, P < .001) and maintained this displacement during SIM (29.4 mm) and SBRT (32.4 mm).
  • A median reduction of 35 mm in the OAR-GTV boundary was observed post-TOD.
  • Complete displacement was achieved in 71% of patients, enabling single-fraction ablative SBRT in 81% without procedure-related complications or OAR toxicities.

Conclusions:

  • Temporary organ displacement (TOD) via drainage catheter and hydrodissection is technically feasible and safe.
  • This technique effectively creates and maintains the necessary separation between the GTV and OAR for radiation therapy.
  • TOD facilitates successful SIM and SBRT, improving treatment safety and potentially efficacy.