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A case of infective endocarditis caused by "Neisseria skkuensis"

Shota Yonetani1, Koji Araki2, Yoshifumi Nishi3

  • 1Department of Medical Technology Faculty of Health Sciences, Kyorin University, Tokyo, Japan; Department of Clinical Laboratory Kyorin University School of Medicine, Tokyo, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|August 31, 2020
PubMed

Insights

This study reports a rare case of infective endocarditis caused by Neisseria skkuensis. 16S rRNA gene sequencing proved crucial for accurate identification of this challenging oral bacterium.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases

Background:

  • Neisseria skkuensis is a gram-negative coccus commonly found in the human oral cavity.
  • Infections caused by N. skkuensis are rare, with limited documented cases in medical literature.

Observation:

  • A case report detailing a male patient in his sixties who presented with infective endocarditis (IE).
  • The IE was confirmed to be caused by N. skkuensis, representing the second reported case identified via 16S rRNA gene sequencing.

Findings:

  • Accurate identification of N. skkuensis poses a significant challenge for clinical microbiology laboratories due to difficulties in biochemical profiling and mass spectrometry.
  • 16S rRNA gene sequencing provided a reliable method for the precise identification of N. skkuensis, outperforming other diagnostic techniques.

Implications:

  • This case highlights the importance of advanced molecular techniques like 16S rRNA gene sequencing for diagnosing infections caused by rare or difficult-to-identify pathogens.
  • Further clinical cases are necessary to establish definitive diagnostic and treatment protocols for N. skkuensis infections.
Keywords:
16S rRNAEndcarditisMALDI-TOF MS“Neisseria skkuensis”

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