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Trisomy 21 and Coronavirus Disease 2019 in Pediatric Patients

Alexander M Newman1, Ravi Jhaveri2, Ami B Patel2

  • 1Ann and Robert H. Lurie Children's Hospital, Chicago, IL.

The Journal of Pediatrics
|August 31, 2020
PubMed

Insights

Children with Down syndrome (trisomy 21) and other health issues face higher risks for severe COVID-19. These pediatric patients require careful monitoring if infected with SARS-CoV-2.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Genetics

Background:

  • Children with trisomy 21 (T21), also known as Down syndrome, often have underlying health conditions.
  • These comorbidities can potentially increase susceptibility to severe infections.

Observation:

  • This study reports on four pediatric patients with T21 and comorbidities who were hospitalized with coronavirus disease 2019 (COVID-19).
  • A literature review was conducted to understand the impact of T21-associated comorbidities on severe disease outcomes.

Findings:

  • Comorbidities frequently seen in individuals with T21 may predispose them to more severe forms of COVID-19.
  • Pediatric patients with T21 and associated health issues are at increased risk for severe outcomes from SARS-CoV-2 infection.

Implications:

  • Children with T21 should be identified as a high-risk group for COVID-19.
  • Enhanced monitoring and proactive management strategies are crucial for pediatric patients with T21 infected with SARS-CoV-2.

Keywords:
COVID-19Down syndrometrisomy 21

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