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Updated: Dec 10, 2025

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Peripherally-sourced myeloid antigen presenting cells increase with advanced aging.

Pedram Honarpisheh1, Frank W Blixt1, Maria P Blasco Conesa1

  • 1University of Texas McGovern Medical School, Department of Neurology, Houston, TX, United States.

Brain, Behavior, and Immunity
|August 31, 2020
PubMed
Summary

Aging alters antigen-presenting cells (APCs) in the brain, gut, and spleen. These age-related immune changes impact the gut microbiota-immune-brain axis, influencing health and disease.

Keywords:
AgingBehaviorDendritic cellsGut microbiota-immune-brain axisMHC-IIMyeloid cellsSex differences

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Area of Science:

  • Neuroimmunology
  • Aging Research
  • Microbiome Science

Background:

  • The gut microbiota-immune-brain axis is crucial for CNS health and disease, with aging disrupting its function.
  • Antigen-presenting cells (APCs) are key regulators of immune responses and are implicated in age-related inflammation and neurodegeneration.
  • Limited data exists on how APCs change across tissues during aging.

Purpose of the Study:

  • To investigate age-related alterations in myeloid APCs within the brain, gut, and spleen.
  • To examine concurrent changes in gut microbiota and behavioral phenotypes in aging mice.
  • To determine if APC changes are tissue-specific and/or sex-specific.

Main Methods:

  • Analysis of myeloid APCs in gut, spleen, and brain across a wide age range (2-32 months) in male and female mice.
  • Assessment of gut microbiota composition.
  • Evaluation of behavioral phenotypes.

Main Results:

  • A significant increase in peripherally-sourced myeloid APCs was observed in the aging brain.
  • Age-related APC alterations demonstrated subset specificity in the gut.
  • Immune cell changes exhibited sexual dimorphism in the spleen.

Conclusions:

  • Myeloid APCs undergo significant age-related changes in the brain, gut, and spleen.
  • These changes are complex, varying by tissue and sex.
  • Future research must consider age, tissue, and sex when studying APCs in the context of aging and disease.