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Application of 3D printing technology for generating hollow-type suppository shells.

Tatsuaki Tagami¹, Erina Ito¹, Naomi Hayashi¹

¹Drug Delivery and Nano Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.

International Journal of Pharmaceutics

|August 31, 2020

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3D printing enables the creation of customized hollow suppositories using polyvinyl alcohol. This technology allows for tailored drug dissolution profiles and the development of novel pediatric formulations, suggesting potential for on-site hospital production.

Area of Science:

Pharmaceutical Technology
3D Printing Applications
Drug Delivery Systems

Background:

The pharmaceutical industry is exploring 3D printing following the FDA approval of a 3D printed tablet.
Hollow-type suppository formulations, often prepared by hospital pharmacists, are a focus for technological advancement.
Existing methods for suppository preparation may lack customization and efficiency.

Purpose of the Study:

To investigate the feasibility of using fused deposition modeling (FDM) 3D printing for hollow suppository shells.
To evaluate the impact of printing parameters on the physical properties of 3D printed suppository shells.
To assess the drug dissolution profiles of active pharmaceutical ingredients loaded into these 3D printed shells.

Main Methods:

Keywords:

3D printing Fused deposition modeling (FDM)Hollow suppository Hospital preparation Ionic liquid Suppository formulation

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Utilized an FDM 3D printer with a water-soluble polyvinyl alcohol filament.

Fabricated hollow suppository shells with varying thicknesses and internal structures by adjusting printing conditions.

Loaded an active pharmaceutical ingredient ionic liquid into the printed shells and analyzed drug dissolution.

Main Results:

The hardness of the 3D printed suppository shells was significantly influenced by shell thickness and internal design.
Drug dissolution profiles varied based on the specific characteristics of the 3D printed suppository shell.
Composite suppository formulations with multiple drugs in separate compartments were successfully prepared as a model for tailored pediatric medicine.

Conclusions:

3D printing technology is a viable method for producing hollow-type suppository formulations.
The technology offers control over physical properties and drug release characteristics.
3D printing holds promise for on-site hospital pharmaceutical production and the creation of personalized medicines, particularly for pediatric applications.