Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.2K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.2K
Long-term Depression01:03

Long-term Depression

2.9K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.9K
Long-term Depression01:05

Long-term Depression

32.7K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.7K
Long-term Potentiation01:25

Long-term Potentiation

3.2K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The vicarious nature of hippocampal theta sequences.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2026
Same author

Hippocampal representations differentiate reactive and anticipatory responses during foraging under threat.

bioRxiv : the preprint server for biology·2026
Same author

Beyond dopamine: Broader neuromodulatory contributions in sign- and goal-tracking.

Psychopharmacology·2026
Same author

The role of nucleus accumbens Fos expression in sex-dependent cocaine-induced locomotion, cocaine self-administration, and primed cocaine seeking in rats.

Behavioural brain research·2026
Same author

The Map's Design: Evolution's Impact on Navigation and Spatial Cognition.

Animals : an open access journal from MDPI·2025
Same author

A Rose in Any Other Context: Context Alters the Responses of Both Birds and Rodents to Novel Objects.

Brain, behavior and evolution·2025

Related Experiment Video

Updated: Dec 10, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.9K

Experience-dependent persistent Arc expression is reduced in the aged hippocampus.

Ali Gheidi1, Chelsey C Damphousse1, Diano F Marrone1

  • 1Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada.

Neurobiology of Aging
|August 31, 2020
PubMed
Summary
This summary is machine-generated.

Aging impairs memory by disrupting hippocampal memory trace replay. This study shows reduced expression of the plasticity gene Arc during rest in aged animals, linking altered neural activity to memory decline.

Keywords:
Arg3.1Immediate-early genePyramidal cellReactivationReplay

More Related Videos

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.1K

Related Experiment Videos

Last Updated: Dec 10, 2025

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

94.9K
Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning
06:03

Author Spotlight: Investigating the Impact of Aging on Hippocampal-Dependent Spatial Learning

Published on: February 16, 2024

2.8K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.1K

Area of Science:

  • Neuroscience
  • Aging Research
  • Cognitive Decline

Background:

  • Aging is associated with memory decline and altered hippocampal function.
  • Memory consolidation involves the reactivation or replay of neural traces during rest.
  • This replay process, particularly in the CA1 region, becomes less synchronized with age.

Purpose of the Study:

  • To investigate the impact of age-related changes in memory replay on plasticity-related gene expression.
  • To test the hypothesis that altered spike timing during replay impairs the induction of plasticity-regulating genes like Arc.
  • To compare Arc transcription patterns during spatial exploration and rest-associated replay in young and aged animals.

Main Methods:

  • Assessed Arc gene transcription in the hippocampal CA1 region.
  • Measured Arc expression during both active spatial exploration and subsequent rest periods.
  • Compared these patterns between young and aged animals.

Main Results:

  • A significant age-related difference was observed in the pattern of pyramidal cells expressing Arc during rest.
  • Aged animals showed altered Arc expression patterns compared to young animals during memory replay.
  • This suggests a disruption in plasticity-related molecular cascades during memory consolidation in aging.

Conclusions:

  • Age-related deficits in memory replay synchronization contribute to impaired plasticity.
  • Altered coordinated neural activity during consolidation in older animals affects plasticity-related gene expression.
  • These molecular changes likely underlie age-related memory decline.