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Microfluidic cloth-based analytical devices: Emerging technologies and applications.

Chunsun Zhang1, Yan Su1, Yi Liang1

  • 1MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China.

Biosensors & Bioelectronics
|August 31, 2020
PubMed
Summary

Microfluidic cloth-based analytical devices (μCADs) offer a low-cost diagnostic solution. This review covers μCAD advancements from 2011-2020, detailing fabrication, components, detection methods, and wearable applications.

Keywords:
Capillary flowClothCloth-based biosensorsMicrofluidic cloth-based analytical devices (μCADs)MicrofluidicsPoint of care testing

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Biomedical Engineering

Background:

  • Cloth is a versatile, low-cost material with properties suitable for diagnostic devices.
  • Microfluidic cloth-based analytical devices (μCADs) emerged in 2011 as an affordable alternative to lab testing.
  • μCADs aim to enhance point-of-care testing and disease screening, particularly in developing regions.

Purpose of the Study:

  • To review advancements in μCAD development from 2011 to 2020.
  • To highlight emerging technologies and applications in the μCAD field.
  • To discuss fabrication methods, functional components, detection techniques, and wearable μCADs.

Main Methods:

  • Review of fabrication methods for μCADs.
  • Discussion of cloth-based microfluidic components (microvalves, micromixers, etc.).
  • Analysis of electroanalytical μCADs and cloth-based electrodes.
  • Categorization of detection methods and their applications.
  • Examination of wearable μCAD development.

Main Results:

  • Fabrication methods and functional components of μCADs are detailed.
  • Electroanalytical techniques and various detection methods are explored.
  • The potential of wearable μCADs is demonstrated.
  • Key trends and future directions in μCAD research are identified.

Conclusions:

  • μCADs represent a significant development in low-cost, user-friendly diagnostic tools.
  • The field has seen substantial progress in fabrication, components, and applications.
  • Future research will likely focus on further integration and novel applications of wearable μCADs.