Related Experiment Video
Updated: Dec 10, 2025
07:00
Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
Published on: October 8, 2018
11.1K
Human genetic background in susceptibility to tuberculosis
Jalaledin Ghanavi1, Poopak Farnia2, Parissa Farnia1
1Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
International Journal of Mycobacteriology
|August 31, 2020
Summary
Genetic factors and microRNAs play a role in tuberculosis (TB) susceptibility and progression. Understanding these elements, including single nucleotide polymorphisms, offers insights into host immune response against Mycobacterium tuberculosis (MTB) infection.
Area of Science:
- Immunology
- Genetics
- Infectious Diseases
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge, particularly in developing nations.
- The precise mechanisms of TB pathogenesis and the genetic factors influencing susceptibility to clinical disease are not fully understood.
- Host genetic variations and post-transcriptional gene regulation by microRNAs (miRNAs) are increasingly recognized as critical determinants of TB outcome.
Purpose of the Study:
- To review and synthesize current literature on the role of genetic polymorphisms and miRNAs in TB pathogenesis and treatment.
- To highlight specific genes and miRNAs associated with susceptibility, resistance, and disease phenotype in TB infection.
- To underscore the potential of miRNAs as biomarkers for distinguishing TB patients from healthy or latently infected individuals.
Main Methods:
- Comprehensive literature review of association studies investigating genetic factors in TB.
- Analysis of research on microRNA expression profiles in TB patients.
- Synthesis of findings linking single nucleotide polymorphisms (SNPs) and miRNAs to TB infection and treatment outcomes.
Main Results:
- Genetic polymorphisms in genes such as TLR, IGRM, VDR, ASAP1, AGMO, FOXP1, and UBLCP1 are associated with TB susceptibility and treatment response.
- MicroRNAs are critical regulators of the host immune response to MTB infection, with differential expression observed in TB patients.
- Altered miRNA expression patterns may serve as potential diagnostic or prognostic markers for TB.
Conclusions:
- Host genetic factors and specific miRNAs significantly influence the host's immune response to Mycobacterium tuberculosis.
- Investigating genetic polymorphisms and miRNA profiles provides valuable insights into TB pathogenesis and disease management.
- Further research into these molecular mechanisms could lead to improved diagnostic tools and therapeutic strategies for tuberculosis.
More Related Videos
Related Concept Videos
01:29Pulmonary Tuberculosis I
625
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
625
01:31Pulmonary Tuberculosis III
705
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
705
01:26Pulmonary Tuberculosis IV
332
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
332
01:28Pulmonary Tuberculosis II
1.1K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.1K
01:28Pulmonary Tuberculosis V
376
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
376
01:28Human Genetics
1.2K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.2K