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Related Experiment Video

Updated: Dec 10, 2025

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
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Update on the Clot Waveform Analysis.

Hideo Wada1,2, Takeshi Matsumoto3, Kohshi Ohishi3

  • 1Department of General and Laboratory Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|September 1, 2020
PubMed
Summary
This summary is machine-generated.

Activated partial thromboplastin time-clot waveform analysis (APTT-CWA) aids in early disseminated intravascular coagulation detection and measures factor VIII activity. This method enhances differential diagnosis and monitors coagulation disorders.

Keywords:
APTTCWADIChemophilia

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Area of Science:

  • Hematology
  • Clinical Chemistry

Background:

  • The activated partial thromboplastin time (APTT) is a standard coagulation test.
  • Early detection of coagulopathies like disseminated intravascular coagulation (DIC) is crucial.
  • Measuring low levels of coagulation factors, such as factor VIII, presents a challenge.

Purpose of the Study:

  • To highlight the utility of APTT-clot waveform analysis (CWA) in clinical diagnostics.
  • To demonstrate APTT-CWA's capability in early DIC detection and factor VIII activity measurement.
  • To explain how APTT-CWA provides insights beyond routine APTT.

Main Methods:

  • Utilizing specialized software to display first and second derivative curves (DCs) from APTT-CWA.
  • Analyzing the height of the first DC for thrombin burst and bleeding risk assessment.
  • Analyzing the height of the second DC for detecting factor deficiencies and phospholipid-induced hypercoagulability.

Main Results:

  • APTT-CWA is associated with early detection of disseminated intravascular coagulation.
  • APTT-CWA can accurately measure very low levels of coagulation factor VIII activity.
  • The first and second derivative curves provide distinct information on thrombin generation dynamics and coagulation abnormalities.

Conclusions:

  • APTT-CWA offers a valuable tool for differential diagnosis in complex coagulation disorders.
  • This method aids in monitoring hemophilia patients and those on anticoagulant therapy.
  • APTT-CWA enhances diagnostic capabilities beyond conventional APTT testing.