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Updated: Dec 10, 2025

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in Patients With Multiple
Charumathi Raghu Subramanian1,2, Swapna Talluri1, Safi Ullah Khan1,3
1Department of Medicine, Guthrie Clinic/Robert Packer Hospital, Sayre, PA, USA.
Background:
Cure rates of Clostridium difficile infection (CDI) with fecal microbiota transplant (FMT) have been promising. However, there is debate regarding success of FMT in patients with comorbidities.
Methods:
Electronic chart review was done to collect data on patients who underwent FMT from January 2015 to August 2017. Charts were analyzed in November 2018 with a median follow-up of 25.4 months (interquartile range 20 - 31 months).
Results:
Twenty patients underwent FMT. The primary success rate at our institution was 90% and overall success rate was 100%. Six patients (43%) had FMT failure (two early and four late).
Conclusions:
This case series is a description of our center's initial experience with FMT for treatment of recurrent CDI. Our high success rate reiterates the efficacy and safety of FMT in this population including patients with comorbidities.
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