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Diabetes Mellitus: Overview and Type I Subtype01:22

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Updated: Dec 10, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Interstitial lung disease and diabetes.

Venkat Rajasurya1, Kulothungan Gunasekaran2, Salim Surani3

  • 1Department of Pulmonary and Critical Care, Novant Health System, Winston-Salem, NC 27103, United States.

World Journal of Diabetes
|September 1, 2020
PubMed
Summary
This summary is machine-generated.

Diabetes mellitus (DM) affects the lungs, potentially causing interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF). This review explores the link between DM and lung conditions, emphasizing IPF progression.

Keywords:
Diabetes complicationsDiabetes mellitusHyperglycemiaIdiopathic pulmonary fibrosisInterstitial lung diseaseMetforminPulmonary function testRestrictive lung disease

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Area of Science:

  • Pulmonology
  • Endocrinology
  • Pathology

Background:

  • Diabetes mellitus (DM) is a global chronic metabolic disease with increasing prevalence.
  • DM complications include microvascular (retinopathy, neuropathy, nephropathy) and macrovascular (cardiovascular) issues.
  • The lungs are also affected by DM due to vascularity and connective tissue, leading to restrictive lung function decline.

Purpose of the Study:

  • To review the lung as a target organ in diabetes mellitus.
  • To explore the association between DM and interstitial lung disease (ILD).
  • To emphasize the specific link between DM and idiopathic pulmonary fibrosis (IPF).

Main Methods:

  • Literature review focusing on DM and lung pathology.
  • Analysis of studies investigating DM-associated microvascular changes in the lungs.
  • Examination of research on fibrosis and connective tissue proliferation in diabetic lungs.

Main Results:

  • DM can cause microvascular complications and extracellular matrix proliferation in the lungs.
  • This can lead to a decline in lung function, often presenting as a restrictive pattern.
  • Interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), is a significant concern in diabetic patients.

Conclusions:

  • The lungs are a significant target organ for diabetes mellitus complications.
  • There is a demonstrable association between DM and the development or exacerbation of ILD, particularly IPF.
  • Further research is warranted to elucidate the mechanisms and clinical implications of DM-ILD/IPF association.