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A Review of Postmortem Findings in Patients With COVID-19

Adenike O Eketunde1, Sai Priyanka Mellacheruvu1, Philip Oreoluwa2

  • 1Public Health, University of Massachusetts Lowell, Lowell, USA.

Cureus
|September 1, 2020
PubMed

Insights

This review examines postmortem findings in COVID-19 patients, focusing on pulmonary, cardiac, and hematologic effects. Understanding these histopathological changes is crucial for diagnosing and managing coronavirus disease.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Public Health

Background:

  • Coronaviruses, including MERS, SARS, and COVID-19, have caused significant global health issues.
  • COVID-19, a pandemic disease, has profoundly impacted global health and daily life.
  • Understanding the pathology of novel viruses like COVID-19 is challenging due to limited autopsy and biopsy data.

Purpose of the Study:

  • To review postmortem gross and histopathological findings in various organs affected by coronavirus.
  • To focus on pulmonary, cardiac, and hematologic findings in COVID-19 patients.
  • To enhance understanding of the mechanism of injury and disease pathology in coronavirus infections.

Main Methods:

  • Systematic literature search using PubMed with keywords related to postmortem findings and COVID-19.
  • Limiting the search to articles published within the last five years.
  • Selection of 25 full-text articles relevant to postmortem findings of COVID-19 for review.

Main Results:

  • The review synthesizes postmortem findings across multiple organ systems affected by COVID-19.
  • Emphasis is placed on detailed pulmonary, cardiac, and hematologic histopathology.
  • The study highlights the morphological changes associated with coronavirus infection.

Conclusions:

  • Postmortem examination provides critical insights into the pathology of COVID-19.
  • Histopathological findings are essential for understanding the systemic effects of coronavirus disease.
  • Further research on autopsy and biopsy data is vital for clarifying disease mechanisms.

Keywords:
cardiovascularcovid19hematologylungspostmortempostmortem pathological findingsrenal

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