COVID-19 in Hospitalized Adults With HIV
Kate Stoeckle1,2, Carrie D Johnston1,3,2, Deanna P Jannat-Khah1,4
1Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Insights
COVID-19 outcomes in people with HIV (PWH) were similar to those without HIV. PWH were hospitalized with less severe hypoxemia, a finding needing further study.
Area of Science:
- Infectious Diseases
- Virology
- Public Health
Background:
- The COVID-19 pandemic caused global morbidity and mortality.
- Clinical outcomes for SARS-CoV-2 and HIV co-infection were unclear.
Purpose of the Study:
- To compare clinical characteristics and outcomes of COVID-19 in hospitalized patients with and without HIV co-infection.
Main Methods:
- Retrospective cohort study of 30 people with HIV (PWH) and 90 controls hospitalized with COVID-19 in NYC.
- Matched analysis based on age, sex, and race/ethnicity.
- Compared demographics, clinical features, and outcomes using electronic health records.
Main Results:
- No significant differences in symptoms, disease duration, lab markers, or chest x-ray findings.
- Patients without HIV required more supplemental oxygen upon presentation.
- No differences in mechanical ventilation, hospital stay duration, or in-hospital mortality.
Conclusions:
- COVID-19 clinical manifestations and outcomes were similar between PWH and controls.
- PWH presented with less severe hypoxemia, requiring further investigation.
Background:
The spread of SARS-CoV-2 and the COVID-19 pandemic have caused significant morbidity and mortality worldwide. The clinical characteristics and outcomes of hospitalized patients with SARS-CoV-2 and HIV co-infection remain uncertain.
Methods:
We conducted a matched retrospective cohort study of adults hospitalized with a COVID-19 illness in New York City between March 3, 2020, and May 15, 2020. We matched 30 people with HIV (PWH) with 90 control group patients without HIV based on age, sex, and race/ethnicity. Using electronic health record data, we compared demographic characteristics, clinical characteristics, and clinical outcomes between PWH and control patients.
Results:
In our study, the median age (interquartile range) was 60.5 (56.6-70.0) years, 20% were female, 30% were black, 27% were white, and 24% were of Hispanic/Latino/ethnicity. There were no significant differences between PWH and control patients in presenting symptoms, duration of symptoms before hospitalization, laboratory markers, or radiographic findings on chest x-ray. More patients without HIV required a higher level of supplemental oxygen on presentation than PWH. There were no differences in the need for invasive mechanical ventilation during hospitalization, length of stay, or in-hospital mortality.
Conclusions:
The clinical manifestations and outcomes of COVID-19 among patients with SARS-CoV-2 and HIV co-infection were not significantly different than patients without HIV co-infection. However, PWH were hospitalized with less severe hypoxemia, a finding that warrants further investigation.
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