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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
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Mild cognitive impairment in Aboriginal Australians
Hannah Derrig1, Louise M Lavrencic1,2,3, Gerald A Broe1,2,3
1Neuroscience Research Australia Sydney New South Wales Australia.
Alzheimer'S & Dementia (New York, N. Y.)
|September 1, 2020
Summary
This study identified distinct risk factors for amnestic and non-amnestic mild cognitive impairment (MCI) in Aboriginal Australians. These findings highlight the need for targeted interventions to reduce dementia risk in this vulnerable population.
Area of Science:
- Neurology
- Public Health
- Gerontology
Background:
- Aboriginal Australians exhibit high dementia rates globally.
- Limited research exists on mild cognitive impairment (MCI) subtypes, risk factors, and outcomes in this population.
Purpose of the Study:
- To investigate MCI subtypes, associated life-course risk factors, and 6-year outcomes in community-dwelling Aboriginal Australians aged 60 years and older.
Main Methods:
- A longitudinal study of 336 Aboriginal Australians aged ≥60 years.
- Cognitive screening, medical assessment, and clinical consensus used for MCI (amnestic and non-amnestic) and dementia diagnosis.
- Logistic regression analyzed associations between life-course factors and MCI subtypes; dementia conversion assessed at 6-year follow-up.
Main Results:
- Prevalent amnestic MCI (aMCI) linked to older age, head injury, depression symptoms, and lower blood pressure.
- Prevalent non-amnestic MCI (naMCI) associated with low education, unskilled work history, higher BMI, and hearing loss.
- At follow-up, 15% of MCI cases reverted, 44% remained stable, and 41% progressed to dementia and/or died.
Conclusions:
- Sociodemographic and clinical factors distinctly contribute to MCI subtypes in Aboriginal Australians.
- Patterns of progression to dementia were similar for both amnestic and non-amnestic MCI subtypes.
Keywords:
Alzheimer's diseaseIndigenousaboriginal Australiansdiagnostic stabilitymild cognitive impairmentmild cognitive impairment subtypespredictive validityrisk factorsMore Related Videos
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