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Related Experiment Video

Updated: Dec 10, 2025

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Published on: January 21, 2020

Antibiotic eluting sinus stents.

Harrison M Thompson¹, Dong-Jin Lim¹, Catherine Banks²

¹Department of Otolaryngology Head and Neck Surgery University of Alabama at Birmingham Birmingham Alabama USA.

Laryngoscope Investigative Otolaryngology

|September 1, 2020

Summary

This summary is machine-generated.

Novel antibiotic-eluting sinus stents show promise for treating chronic rhinosinusitis (CRS). These innovative devices, particularly those combining antibiotics with other agents, demonstrate improved efficacy in reducing bacterial load and biofilm in animal models, warranting human trials.

Keywords:

antibiotic stent azithromycin biofilm chronic rhinosinusitis ciprofloxacin cystic fibrosis ivacaftor sinus stent sinusitis stent

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Area of Science:

Otolaryngology
Infectious Diseases
Biomedical Engineering

Background:

Chronic rhinosinusitis (CRS) affects up to 16% of the US population, with a higher prevalence in cystic fibrosis (CF) patients.
Systemic antibiotics have limited efficacy in alleviating CRS symptom burden.
Novel therapeutic strategies are needed for refractory CRS cases, especially in CF patients.

Purpose of the Study:

To review recent research on antibiotic-eluting sinus stent therapy for CRS.
To discuss in vitro and animal model studies evaluating the efficacy of these novel stents.
To identify factors contributing to the efficacy of antibiotic-eluting sinus stents.

Main Methods:

PubMed literature review.
Comprehensive review of published literature on antibiotic-eluting sinus stents.
Integration and summarization of findings on this innovative approach for chronic sinus infections.

Main Results:

Ciprofloxacin sinus stent (CSS) and ciprofloxacin-ivacaftor sinus stent (CISS) improved endoscopic and radiographic findings in rabbit CRS models.
CSS showed a trend toward microscopic improvement and biofilm reduction, but initial burst release led to persistent planktonic bacteria.
CISS and ciprofloxacin-azithromycin sinus stents (CASSs) demonstrated controlled antibiotic release, significantly reducing planktonic bacteria and biofilm mass. In vitro studies suggest CASS efficacy in biofilm reduction.

Conclusions:

Antibiotic-eluting sinus stents represent a promising novel therapeutic strategy for CRS.
CISS may offer dual benefits for CF patients by addressing infectious and genetic factors.
Animal studies support the translation of antibiotic sinus stents into human clinical trials, which are warranted to confirm efficacy.