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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Published on: April 26, 2017

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Aberrant RNA Splicing in Cancer

Luisa Escobar-Hoyos1,2,3, Katherine Knorr4, Omar Abdel-Wahab1,4,5

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Annual Review of Cancer Biology
|September 1, 2020
PubMed

Insights

Altered RNA splicing is a key driver in cancer development. Targeting these splicing changes offers a promising new therapeutic strategy for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Genomics
  • RNA Biology

Background:

  • RNA splicing is crucial for protein diversity and gene expression regulation.
  • Cancer cells exhibit significant alterations in RNA splicing compared to normal cells.
  • Mutations in splicing factors are frequently observed in various cancers, implicating them in tumorigenesis.

Purpose of the Study:

  • To review recent findings on global RNA splicing changes in cancer.
  • To explore the role of splicing in regulating cancer-driving mitogenic pathways.
  • To summarize current therapeutic strategies targeting RNA splicing in cancer.

Main Methods:

  • Review of recent scientific literature on RNA splicing in cancer.
  • Analysis of genomic and transcriptomic sequencing data from cancer studies.
  • Examination of studies on small molecules designed to disrupt splicing.

Main Results:

  • Global RNA splicing patterns are significantly altered in cancer.
  • Splicing regulates critical mitogenic pathways involved in cancer transformation.
  • Therapeutic targeting of splicing is an emerging strategy in cancer treatment.

Conclusions:

  • Aberrant RNA splicing is a significant factor in cancer development.
  • Pharmacological modulation of RNA splicing holds therapeutic potential for cancer patients.
  • Further research into splicing alterations and targeted therapies is warranted.
Keywords:
RNASF3B1SRSF2U2AF1ZRSR2splicing

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