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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
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Cell-Membrane-Targeted Drug Delivery System Based on Choline-Phosphate-Functionalized β-Cyclodextrin
Ying Feng1, Qiangwei Xin1, Wanlin Zhang1
1College of Medicine, Southwest Jiaotong University, Chengdu, 610031, P. R. China.
Macromolecular Bioscience
|September 1, 2020
Summary
A novel choline phosphate (CP)-functionalized β-cyclodextrin (CP-β-CD) enhances drug delivery by improving solubility and cell uptake. This non-toxic system shows potential for targeted anti-angiogenesis therapies.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Nanotechnology
Background:
- Cyclodextrins are widely used in drug delivery but often suffer from poor water solubility.
- Targeting cell membranes is crucial for efficient drug delivery and therapeutic efficacy.
Purpose of the Study:
- To synthesize and characterize a novel zwitterionic choline phosphate (CP)-functionalized β-cyclodextrin (CP-β-CD).
- To evaluate the potential of CP-β-CD as a drug delivery system for hydrophobic drugs, focusing on solubility, cell uptake, and anti-angiogenesis activity.
Main Methods:
- Synthesis of CP-β-CD via click chemistry.
- Solubility studies of CP-β-CD and drug-loaded CP-β-CD.
- In vitro cytotoxicity assays.
- Evaluation of anti-angiogenesis activity using apatinib as a model drug.
Main Results:
- CP-β-CD was successfully synthesized with significantly improved water solubility (816 mg mL⁻¹).
- CP-β-CD demonstrated excellent cell-membrane targeting and enhanced cellular uptake.
- Drug-loaded CP-β-CD exhibited potent anti-angiogenesis activity with no observed cytotoxicity.
Conclusions:
- CP-β-CD is a non-toxic, highly water-soluble cyclodextrin derivative with superior cell internalization efficiency.
- This novel material holds significant promise for developing advanced drug delivery systems, particularly for hydrophobic drugs targeting angiogenesis.
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