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Published on: October 28, 2021
Clinical factors affecting prognosis of limb osteosarcoma in China: a multicenter retrospective analysis
Jia Han1, Yiyang Yu2, Sujia Wu3
1Department of Orthopedics, PLA 960th Hospital, Jinan City, Shandong Province, China.
Objective:
This study was performed to explore the relationship between various clinical factors and the prognosis of limb osteosarcoma.
Methods:
We retrospectively analyzed the clinical data of 336 patients with limb osteosarcoma treated from June 2000 to August 2016 at 7 Chinese cancer centers. Data on the patients' clinical condition, treatment method, complications, recurrences, metastasis, and prognosis were collected and analyzed. Kaplan-Meier analysis and Cox regression models were used to analyze the data.
Results:
The patients comprised 204 males and 132 females ranging in age from 6 to 74 years (average, 21.1 years). The overall 3- and 5-year survival rates were 65.0% and 55.0%, respectively. The 5-year overall survival rate was 64.0% with standard chemotherapy and 45.6% with non-standard chemotherapy. Cox regression analysis demonstrated that standard chemotherapy, surgery, recurrence, and metastasis were independent factors associated with the prognosis of limb osteosarcoma.
Conclusion:
The survival of patients with limb osteosarcoma can be significantly improved by combining standard chemotherapy and surgery. The overall survival rate can also be improved by adding methotrexate to doxorubicin-cisplatin-ifosfamide triple chemotherapy.
