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Retrospective analysis of clinical characteristics of 405 patients with COVID-19
Ting Zhan1, Meng Liu1, Yalin Tang1,2
1Department of Gastroenterology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China.
Insights
This study details the clinical features of hospitalized patients with coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. Older age, comorbidities, and lab abnormalities indicate severe COVID-19 illness.
Area of Science:
- Infectious Diseases
- Pulmonology
- Virology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19).
- Understanding COVID-19 clinical characteristics is crucial for patient management.
Purpose of the Study:
- To investigate the clinical characteristics of hospitalized patients with COVID-19.
- To identify factors associated with disease severity.
Main Methods:
- Retrospective analysis of electronic medical records.
- Inclusion of 405 hospitalized patients with laboratory-confirmed COVID-19.
- Data collection on demographics, clinical manifestations, comorbidities, and laboratory findings.
Main Results:
- Median age of patients was 56 years; 54.1% were female.
- Common symptoms included fever (76.8%) and cough (53.3%).
- Lymphopenia (72.3%), hypoproteinemia (71.6%), and abnormal liver function (20%) were frequent. Severe cases showed more pronounced laboratory abnormalities.
Conclusions:
- SARS-CoV-2 causes severe respiratory illness, similar to SARS-CoV-1.
- Older age, pre-existing comorbidities, and specific laboratory abnormalities are linked to increased COVID-19 severity.
Objective:
This study was performed to investigate the clinical characteristics of patients with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods:
We analyzed the electronic medical records of 405 hospitalized patients with laboratory-confirmed COVID-19 in the Third Hospital of Wuhan.
Results:
The patients' median age was 56 years, 54.1% were female, 11.4% had a history of smoking, and 10.6% had a history of drinking. All cases of COVID-19 were community-acquired. Fever (76.8%) and cough (53.3%) were the most common clinical manifestations, and circulatory system diseases were the most common comorbidities. Gastrointestinal symptoms were present in 61.2% of the patients, and 2.9% of the patients were asymptomatic. Computed tomography showed ground-glass opacities in most patients (72.6%) and consolidation in 30.9%. Lymphopenia (72.3%) and hypoproteinemia (71.6%) were observed in most patients. About 20% of patients had abnormal liver function. Patients with severe disease had significantly more prominent laboratory abnormalities, including an abnormal lymphocyte count and abnormal C-reactive protein, procalcitonin, alanine aminotransferase, aspartate aminotransferase, D-dimer, and albumin levels.
Conclusion:
SARS-CoV-2 causes a variety of severe respiratory illnesses similar to those caused by SARS-CoV-1. Older age, chronic comorbidities, and laboratory abnormalities are associated with disease severity.
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