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Published on: March 21, 2015
Role of oxidative stress in epileptogenesis and potential implications for therapy
Kinga K Borowicz-Reutt1, Stanisław J Czuczwar2
1Independent Unit of Experimental Pathophysiology, Medical University of Lublin, Lublin, Poland. kingaborowicz@umlub.pl.
Abstract:
In a state of balance between oxidants and antioxidants, free radicals play an advantageous role of "redox messengers". In a state of oxidative stress, they trigger a cascade of events leading to epileptogenesis. During this latent, free of seizures period, a cascade of neurological changes takes place and finally leads to spontaneous recurrent seizures. The main processes involved in seizure generation are: neuroinflammation, neurodegeneration with anomalous neuroregeneration and lowering seizure threshold. Time of epileptogenesis offers a unique therapeutic window to prevent or at least attenuate seizure development. Animal data indicate that some antioxidants (for instance, resveratrol) may bear an anti-epileptogenic potential.
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