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Updated: Dec 10, 2025

Methodology for Accurate Detection of Mitochondrial DNA Methylation
Published on: May 20, 2018
Brain metabolic DNA: recent evidence for a mitochondrial connection
Antonio Giuditta1, Gigliola Grassi Zucconi2, Adolfo Sadile3
1Accademia di Scienze Fisiche e Matematiche, Via Mezzocannone 8, Naples, I-80134,Italy.
Abstract:
This review highlights recent data concerning the synthesis of brain metabolic DNA (BMD) by cytoplasmic reverse transcription and the prompt acquisition of the double-stranded configuration that allows its partial transfer to nuclei. BMD prevails in the mitochondrial fraction and is present in presynaptic regions and astroglial processes where it undergoes a turnover lasting a few weeks. Additional data demonstrate that BMD sequences are modified by learning, thus indicating that the modified synaptic activity allowing proper brain responses is encoded in learning BMD. In addition, several converging observations regarding the origin of BMD strongly suggest that BMD is reverse transcribed by mitochondrial telomerase.
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