Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.8K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.8K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

547
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
547
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

319
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
319
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Hypertension I: Introduction01:28

Hypertension I: Introduction

530
Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
530
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

413
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
413

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxicological evaluation of entricitabine and tenofovir disoproxyl fumarate, isolated and mixture, in cyanobacteria and microalgae.

The Science of the total environment·2025
Same author

Chronic Treatment with Curcumin Prevents Vascular Dysfunction in the Aorta of Type 1 Diabetes by Restoring Ca<sup>2+</sup> Mishandling and Modulating HSP70 Levels.

Cells·2025
Same author

Blockade of HSP70 Improves Vascular Function in a Mouse Model of Type 2 Diabetes.

Cells·2025
Same author

Removal of the Active Pharmaceutical Substance Entecavir from Water via the Fenton Reaction or Action by the Cyanobacterium <i>Microcystis novacekii</i>.

Toxics·2025
Same author

Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction.

Cardiovascular research·2024
Same author

Obesity Is a Major Determinant of Impaired Cardiac Energy Metabolism in Heart Failure with Preserved Ejection Fraction.

The Journal of pharmacology and experimental therapeutics·2023

Related Experiment Video

Updated: Dec 10, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

602

Hypertension and Erectile Dysfunction: Breaking Down the Challenges.

Amanda Almeida de Oliveira1, Kenia Pedrosa Nunes1

  • 1Laboratory of Vascular Physiology, Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, Florida, USA.

American Journal of Hypertension
|September 1, 2020
PubMed
Summary

Hypertension and erectile dysfunction (ED) are linked by endothelial dysfunction. This review explores how hypertension impacts vascular health and ED, involving oxidative stress and inflammation.

Keywords:
antihypertensive drugsblood pressureerectile dysfunctionhypertensionimmune systemvasoconstrictorsvasodilators

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.0K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Related Experiment Videos

Last Updated: Dec 10, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

602
Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.0K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Area of Science:

  • Cardiovascular Science
  • Urology
  • Immunology

Background:

  • Hypertension diagnosis elevates erectile dysfunction (ED) risk, and ED can signal hypertension.
  • Endothelial dysfunction is a key shared mechanism linking hypertension and ED.
  • Hypertension disrupts vascular balance, impacting erectile structures via procontractile factors and oxidative stress.

Purpose of the Study:

  • To review mechanisms connecting hypertension and ED.
  • To emphasize the role of the vasculature and penile corpora cavernosa signaling networks.

Main Methods:

  • Review of established and emerging scientific literature.
  • Focus on pathophysiological mechanisms.
  • Analysis of signaling pathways in hypertension and ED.

Main Results:

  • Hypertension-induced procontractile factors (angiotensin II, endothelin 1, aldosterone) impair vascular and erectile function.
  • Increased reactive oxygen species and oxidative stress are prominent in hypertension and ED.
  • The innate immune system, particularly Toll-like receptor 4, contributes to hypertension and ED pathophysiology via inflammation and oxidative stress.

Conclusions:

  • Understanding the shared pathophysiology of hypertension and ED is crucial.
  • Targeting vascular and immune pathways may offer therapeutic strategies for both conditions.
  • Drug-induced ED in hypertensive patients necessitates careful treatment considerations.