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Vascular Calcifications are Associated with Increased Mortality in Patients with Acute Mesenteric Ischemia

Fabien Lareyre1, Emmanuel Augène2, Damien Massalou2

  • 1Department of Vascular Surgery, University Hospital of Nice, France; Université Côte d'Azur, CHU, Inserm U1065, C3M, Nice, France.

Annals of Vascular Surgery
|September 1, 2020
PubMed

Insights

Vascular calcifications in the superior mesenteric artery predict higher mortality in acute mesenteric ischemia patients. This finding highlights calcification as a significant risk factor in this critical condition.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Radiology

Background:

  • Vascular calcifications are known mortality predictors in cardiovascular diseases.
  • Their role in acute mesenteric ischemia (AMI) remains unexplored.
  • This study investigates the impact of vascular calcifications in AMI patients.

Purpose of the Study:

  • To determine the association between vascular calcifications and mortality in patients with acute mesenteric ischemia.
  • To assess the prevalence and location of vascular calcifications in AMI patients.

Main Methods:

  • Retrospective analysis of patients admitted for acute mesenteric ischemia.
  • Computed tomography (CT) scans used to assess calcifications in the visceral aorta, celiac trunk, superior mesenteric artery (SMA), and renal arteries.
  • Calcification volumes measured using Aquarius iNtuition Edition software.

Main Results:

  • High all-cause mortality rate (63.9%) observed in 86 AMI patients over a median follow-up of 3.5 days.
  • Significantly lower survival rate in patients with SMA calcification (22% vs. 55.6%, P=0.019).
  • Increased frequency of calcifications in SMA, visceral aorta, celiac trunk, and renal arteries among non-survivors.

Conclusions:

  • Vascular calcifications in the superior mesenteric artery are linked to increased mortality in acute mesenteric ischemia.
  • These findings suggest vascular calcifications as a potential prognostic marker in AMI.
  • Further research is needed to elucidate the underlying mechanisms of this association.
Abstract

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