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Updated: Dec 10, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.4K

Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis

Sahar Sarmasti Emami1, Derek Zhang1, Xiaolong Yang1

  • 1Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON K7L 3N6, Canada.

Cancers
|September 2, 2020
PubMed

Insights

The Hippo pathway, crucial for cell processes, is regulated by kinases and phosphatases. Understanding phosphatase roles in Hippo signaling is key for developing new cancer therapies.

Area of Science:

  • Cellular signaling pathways
  • Molecular biology
  • Cancer research

Background:

  • The Hippo pathway is a critical tumor suppressor pathway regulating cell proliferation and organ size.
  • Dysregulation of the Hippo pathway is implicated in various diseases, notably cancer.
  • Kinase regulation of the Hippo pathway is well-documented, but phosphatase involvement is less understood.

Purpose of the Study:

  • To review recent findings on phosphatases regulating the Hippo pathway in tumorigenesis.
  • To highlight challenges in elucidating phosphatase roles within the Hippo pathway.
  • To outline future research directions for phosphatase-Hippo pathway crosstalk.

Main Methods:

  • Literature review of recent scientific reports.
  • Synthesis of current knowledge on phosphatase interactions with the Hippo pathway.
  • Analysis of challenges and future prospects in the field.

Main Results:

  • Phosphatases play a significant, yet underappreciated, role in modulating Hippo pathway activity.
  • Specific phosphatases are emerging as key regulators of YAP/TAZ, the Hippo pathway's downstream effectors.
  • The interplay between phosphatases and the Hippo pathway presents novel therapeutic targets for cancer.

Conclusions:

  • Phosphatases are critical regulators of the Hippo signaling pathway and its role in cancer.
  • Further research into phosphatase-mediated regulation of the Hippo pathway is essential for advancing cancer therapeutics.
  • Clarifying the complex crosstalk between phosphatases and the Hippo pathway will unlock new treatment strategies.
Keywords:
Hippo pathwayLATSMSTTAZYAPprotein phosphatasetumorigenesis

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