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Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
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Biomaterials for Bioprinting Microvasculature
Ryan W Barrs1,2, Jia Jia1,2, Sophia E Silver1,2
1Bioengineering Department, Clemson University, Clemson, South Carolina 29634, United States.
Chemical Reviews
|September 2, 2020
Summary
Developing functional microvasculature via three-dimensional bioprinting is challenging. This review critically evaluates biomaterials and hydrogel bioinks essential for creating complex, printable microvascular networks for tissue engineering and disease modeling.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Microvasculature is crucial for tissue oxygen and nutrient exchange.
- Engineering functional microvasculature is complex due to its size and intricate structure.
- Traditional methods have limitations in replicating microvascular complexity.
Purpose of the Study:
- To critically evaluate contemporary biomaterials for bioprinting microvasculature.
- To analyze the role of hydrogel bioinks in microvascular network formation.
- To review applications and future challenges in microvascular bioprinting.
Main Methods:
- Comprehensive literature review of bioprinting techniques for microvessels.
- In-depth analysis of hydrogel bioink properties and performance.
- Examination of recent applications in disease modeling, drug testing, and tissue engineering.
Main Results:
- Three-dimensional bioprinting enables precise fabrication of microvascular systems.
- Hydrogel bioinks are key for promoting robust microvascular network formation and organization.
- Significant challenges remain in designing biomaterials for physiologically complex microvasculature.
Conclusions:
- Biomaterials are critical for advancing microvascular bioprinting.
- Further development of printable biomaterials is needed for complex microvascular applications.
- Bioprinted microvasculature holds promise for disease modeling, drug testing, and tissue regeneration.
