Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary central nervous system lymphoma.

F H Hochberg1, D C Miller

  • 1Department of Neurology, Massachusetts General Hospital, Boston.

Journal of Neurosurgery
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using machine learning to advance synthesis and use of conservation and environmental evidence.

Conservation biology : the journal of the Society for Conservation Biology·2018
Same author

MHC haplotype diversity in Persian Arabian horses determined using polymorphic microsatellites.

Immunogenetics·2017
Same author

Deregulated expression of EZH2 in congenital brainstem disconnection.

Neuropathology and applied neurobiology·2016
Same author

Variation in the use of postoperative radiotherapy among high-risk patients following radical prostatectomy.

Prostate cancer and prostatic diseases·2016
Same author

Twin Problems of Interfacial Carbonate Formation in Nonaqueous Li-O2 Batteries.

The journal of physical chemistry letters·2015
Same author

Molecular evidence for natural killer-like cells in equine endometrial cups.

Placenta·2012
Same journal

A novel surgical T staging system for recurrent nasopharyngeal carcinoma: advancing prognostic accuracy and clinical applicability.

Journal of neurosurgery·2026
Same journal

De novo aneurysm formation and untreated aneurysm growth after microsurgical clipping: a 20-year prospective cohort study.

Journal of neurosurgery·2026
Same journal

Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

Journal of neurosurgery·2026
Same journal

A nomogram predicting postoperative recurrence risk in SF1/TPIT nonfunctioning pituitary neuroendocrine tumors: integration of tumor heterogeneity quantification on T2-weighted imaging.

Journal of neurosurgery·2026
Same journal

Resection plus stereotactic radiosurgery versus stereotactic radiosurgery alone and control of brain metastasis-induced seizures.

Journal of neurosurgery·2026
Same journal

Predictors of ventricular shunt survival in neoplastic hydrocephalus: a retrospective cohort study of 239 patients.

Journal of neurosurgery·2026
See all related articles

Primary central nervous system (CNS) lymphoma is rare but increasing, especially in AIDS patients. Chemotherapy shows promise for treating this brain tumor, unlike radiation therapy.

Area of Science:

  • Neurology
  • Oncology
  • Immunology

Background:

  • Primary central nervous system (CNS) lymphoma is a rare brain tumor, accounting for less than 1% of all primary brain tumors.
  • Its incidence has tripled in non-immunosuppressed individuals over the past decade and is projected to become the most common neurological neoplasm by 1991.
  • A significant percentage of acquired immunodeficiency syndrome (AIDS) patients develop CNS lymphoma, and individuals with inherited or acquired immune disorders are also predisposed.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, and treatment of primary CNS lymphoma.
  • To highlight the increasing incidence and association with immunosuppression, including AIDS.
  • To discuss current and emerging therapeutic strategies for CNS lymphoma.

Main Methods:

Related Experiment Videos

  • Review of existing literature on primary CNS lymphoma.
  • Analysis of epidemiological trends and risk factors, including immunosuppression and Epstein-Barr virus association.
  • Evaluation of treatment outcomes for radiation therapy and various chemotherapy regimens.

Main Results:

  • Primary CNS lymphoma incidence is rising, particularly in the AIDS population.
  • Epstein-Barr virus is implicated in the pathogenesis of CNS lymphoma.
  • Chemotherapy regimens, including high-dose methotrexate and CHOP, demonstrate uniform complete responses in intracranial deposits, contrasting with poor outcomes from radiation therapy.

Conclusions:

  • Primary CNS lymphoma is an increasingly recognized malignancy, strongly linked to immune status.
  • Chemotherapy offers superior efficacy for CNS lymphoma compared to radiation therapy.
  • Further research into optimal treatment strategies, especially for immunocompromised patients, is warranted.