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Updated: Dec 10, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Does obstructive sleep apnoea contribute to obesity, hypertension and kidney dysfunction in children? A systematic

Sara Rodriguez-Lopez1,2, Stefan Palkowski2,3, Christopher Gerdung2,4

  • 1Nephrology, Stollery Children's Hospital, Edmonton, Alberta, Canada.

BMJ Open
|September 2, 2020
PubMed

Insights

Childhood obstructive sleep apnoea (OSA) is common and may link to obesity, high blood pressure, and kidney issues. This review synthesizes evidence on OSA

Area of Science:

  • Pediatric Sleep Medicine
  • Cardiovascular Health in Children
  • Renal Function and Sleep Disorders

Background:

  • Childhood obstructive sleep apnoea (OSA) is a prevalent condition with suspected links to obesity, hypertension, and renal injury.
  • Existing evidence on these associations in children is conflicting, necessitating an updated synthesis.
  • Understanding these relationships is crucial for guiding interventions in pediatric OSA management.

Purpose of the Study:

  • To systematically review and summarize the evidence on the impact of childhood OSA on obesity, systemic blood pressure, and kidney function.
  • To evaluate the potential of respiratory interventions for OSA to improve these associated health outcomes in children.

Main Methods:

  • A comprehensive systematic literature search was conducted across multiple databases (Ovid Medline, Embase, CINAHL, Cochrane Library, ProQuest) up to February 25, 2020.
  • Studies involving children with OSA and data on weight, blood pressure, or kidney parameters were included after dual-reviewer screening.
  • Risk of bias and certainty of evidence were assessed using established methodologies (e.g., GRADE).

Main Results:

  • Data extraction and analysis will categorize findings based on specific outcomes (obesity, blood pressure, kidney function).
  • The review will provide a synthesized overview of the current evidence, highlighting consistencies and discrepancies.
  • Specific results on the association strength and direction will be detailed upon completion of the analysis.

Conclusions:

  • This systematic review will offer critical insights for healthcare professionals regarding the links between childhood OSA and key health indicators.
  • Findings are expected to inform the development of targeted strategies and future research directions for pediatric OSA.
  • Dissemination through conferences and publications will ensure broad accessibility of the synthesized evidence.
Abstract

Keywords:
paediatric nephrologypaediatric thoracic medicinesleep medicine

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