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Related Experiment Video

Updated: Dec 10, 2025

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

Stress Impairs Intentional Memory Control through Altered Theta Oscillations in Lateral Parietal Cortex.

C W E M Quaedflieg^1,2, T R Schneider³, J Daume³

¹Department of Cognitive Psychology, Institute of Psychology, Universität Hamburg, Hamburg 20146, Germany conny.quaedflieg@maastrichtuniversity.nl lars.schwabe@uni-hamburg.de.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|September 2, 2020

Summary

This summary is machine-generated.

Acute stress impairs our ability to intentionally forget unwanted memories. This stress-induced memory control deficit is linked to altered brain activity and connectivity, impacting conditions like PTSD.

Keywords:

cortisol memory memory suppression stress theta

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Last Updated: Dec 10, 2025

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Published on: February 6, 2019

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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

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Published on: June 29, 2018

Area of Science:

Cognitive Neuroscience
Psychology
Neurobiology

Background:

Forgetting can be an active, intentional process, not just passive decay.
Understanding factors influencing intentional memory control is crucial, especially for mental health.
Stress may disrupt the brain mechanisms underlying memory control.

Purpose of the Study:

To investigate if acute stress disrupts intentional memory control.
To explore the neural mechanisms behind stress-induced deficits in memory suppression.
To examine the link between stress hormones, brain activity, and memory control.

Main Methods:

Healthy participants underwent a stress or control procedure.
Participants intentionally retrieved or suppressed learned cue-target pairs.
Magnetoencephalography (MEG) and cortisol levels were measured.

Main Results:

Stress abolished suppression-induced forgetting observed in controls.
Altered theta activity in temporal and parietal cortex correlated with stress and cortisol.
Reduced hippocampus-PFC connectivity was linked to increased cortisol.

Conclusions:

Acute stress significantly impairs the capacity for intentional forgetting.
Neural mechanisms involving parietal cortex activity and hippocampus-PFC connectivity are implicated in this deficit.
Findings offer insights into memory dysfunction in stress-related disorders like PTSD.