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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Multi-species Conserved Sequences02:51

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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Related Experiment Video

Updated: Dec 10, 2025

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
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Evolutionary and Functional Analysis of Korean Native Pig Using Single Nucleotide Polymorphisms.

Jongin Lee1, Nayoung Park1, Daehwan Lee1

  • 1Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea.

Molecules and Cells
|September 2, 2020
PubMed
Summary

This study analyzed Korean native pig (KNP) genomics, revealing its evolutionary path and unique traits. Findings offer insights into KNP evolution and domestication using comparative and population genomics.

Keywords:
Korean native pigdomesticationevolutionsingle nucleotide polymorphism

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Animal Science

Background:

  • Population-scale sequencing enables evolutionary studies of species-specific traits.
  • Understanding domestic animal evolution is crucial for trait insights.

Purpose of the Study:

  • To perform evolutionary and functional analysis of Korean native pigs (KNP).
  • To investigate KNP's evolutionary history and unique genes using genomic data.
  • To compare KNP with other mammals and pig breeds.

Main Methods:

  • Comparative and population genomic approaches.
  • Analysis of single nucleotide polymorphism (SNP) data.
  • Examination of non-synonymous SNPs for unique gene identification.

Main Results:

  • Discovered the evolutionary trajectory of KNP SNPs within mammalian species and pig breeds.
  • Identified olfaction-associated functions diversified during KNP evolution.
  • Found quantitative trait loci linked to KNP's unique characteristics.

Conclusions:

  • Provides new insights into Korean native pig evolution and domestication.
  • Demonstrates the utility of combined comparative and population genomics for domestic animal studies.